We are in constant pursuit of breakthroughs that change patients' lives. We drive innovation daily to make the world a better place. This was Charles Pfizer's initial vision, and it remains true today. Evidence confirms what we instinctively know: that purpose-driven companies achieve more, are more inventive, draw and keep the best people, and know how to harness the power of those individuals. Pfizer's purpose—Breakthroughs that improve patients' lives—powers everything we do and reflects our passion for building on our legacy as one of the most important contributors of good to the world. Each word in our purpose has significance and embodies the value we aim to bring to patients and society. Our purpose guarantees that patients continue to be at the centre of all we do. We embody our purpose by seeking the best science in the world, collaborating with others in the healthcare system to enhance access to our medicines, using digital technologies to advance our drug discovery and development, as well as patient outcomes, and leading the conversation to advocate for pro-innovation/pro-patient policies. Every determination we make, and every move we take is done with the patient in mind—and to nurture an environment where breakthroughs can prosper.