We are in constant pursuit of breakthroughs that transform patients' lives. We create innovations every day to make the world a better place. This was Charles Pfizer's initial vision, and it remains true today. Evidence confirms what intuition tells us: that purpose-driven companies achieve more, are more innovative, attract and retain the best people, and know how to harness the power of those people. Pfizer's purpose—Breakthroughs that transform patients' lives—powers everything we do and shows our passion for building on our legacy as one of the most meaningful contributors of good to the world. Each word in our purpose has significance and represents the value we aim to bring to patients and society. Our purpose guarantees that patients remain at the centre of all we do. We embody our purpose by sourcing the best science in the world, working with others in the healthcare system to enhance access to our medicines, using digital technologies to advance our drug discovery and development, as well as patient outcomes, and driving the conversation to advocate for pro-innovation/pro-patient policies. Every determination we make, and every step we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.